File Name: cellular and humoral immunity .zip
Humoral immunity or humoural immunity is the aspect of immunity that is mediated by macromolecules found in extracellular fluids such as secreted antibodies , complement proteins , and certain antimicrobial peptides.
- Difference Between Humoral and Cell-Mediated Immunity
- 11.5A: Humoral Immune Response
- Humoral immunity
Difference Between Humoral and Cell-Mediated Immunity
The primary difference between them is the mechanism of immunity , where the Humoral immunity produces antibodies against the antigens which are present outside the infected cells or free circulating in the blood. Cell-mediated immunity works inside the infected cells, where it destroyed the pathogens or microorganisms by the process of lysis by the releasing cytokines. Humoral immunity shows quick response against the pathogens, while cell-mediated immunity is slow in action. Both the type are part of the adaptive immune system.
Our immune system provides the protection and resistance against the infectious disease, which is offered by the host cell present in the body. The immune system has complex networks of the molecules, cells and their interactions are designed to eradicate the infectious organisms from the body. Immunity or immune system is divided into two types — innate non-specific and acquired or adaptive specific immunity.
The innate immunity works as defensive barriers and represents the capability of the organisms to protect against any disease. On the other hand, the acquired immunity represents the most potent line of defense mechanisms in the body, which is known for identifying and destroying the specific pathogens or any foreign particles which are harmful to the body. The acquired or adaptive immunity display four major characteristics, like Recognition diversity; Immunological memory; Antigen specificity; and Discrimination among self and non-self.
In this content, we will be studying the Humoral and the cell-mediated immunity, which is the part of the adaptive or acquired immunity. We will also focus on the points on which these terms distinguish, with a brief summary.
Basis for Comparison Humoral Immunity Cell-Mediated Immunity Meaning The humoral immunity is associated with the B-lymphocytes and is responsible for destroying the pathogens by producing antibodies against it. The cell-mediated immunity is associated with the T-lymphocytes and is responsible for destroying the pathogens or microorganism which have invaded the cells. Mediated by Humoral immunity is intimately associated with B-lymphocytes, T-lymphocytes and macrophages. These are associated with T-lymphocytes, helper T cells, natural killer cells and macrophages.
Antibodies Present. Function 1. It plays a major role in recognizing antigen or any foreign particle and in producing antibodies against it. Humoral immunity is known for working against extracellular pathogens. Cell-mediated immunity is related to T-lymphocytes, which work by identifying viruses and microorganisms,thus destroying them by the cell lysis or phagocytosis or pinocytosis.
It is known for working against intracellular pathogens. Secretes It secrets antibodies. It secretes cytokines. Action against pathogen Humoral immunity is rapid or quick in their response. The Cell-mediated immunity show delay though permanent action against any pathogens. Cell-mediated is the delayed in response and mediates hypersensitivity type IV. Rejections Humoral immunity is involved in the early stage of graft rejections due to the formation of antibodies. Cell-mediated immunity is involved in the rejection of organ transplants.
Humoral immune response or antibody-mediated response is associated with the B cells, where the role of these cells B cells is to identify the antigens or any foreign particle that are present in the circulation in blood or lymph. This immune response is also assisted with helper T cells which along with the B cells get differentiated into plasma B cells that can produce antibodies.
As soon as B cells produce antibodies, they will bind to an antigen; neutralize them and causes phagocytosis or cell lysis destruction of the cells.
The antigen is the foreign particle, which is usually a carbohydrate or a protein that triggers an immune response, but above that our body has tremendous capability to identify the antigens. Any kind exposure of antigens leads to the development of secondary immunological response which increases the level of the immune response. The immunoglobulins or antibodies mediate the humoral immunity, these are a particular group of proteins produced by the B-lymphocytes.
T lymphocytes assist the Cell-mediated immunity or cellular immunity. In this type, cytokines have released that help to activate the T cells which further destroys the infected cell. Likewise the B cells, T cells originate in bone marrow but matures in the thymus and later gets circulate in the bloodstream and lymphoid tissue. Abnormal or aberrant MHC molecules are formed from the antigens which have been destroyed or broken down or from any infected virus exogenous antigens or the from tumour cells that are actively producing foreign proteins endogenous antigens.
Now helper T-cells release the cytokines, that will activate the T cells, which will recognize the aberrant MHC-antigen complex and will bind to it and differentiate into cytotoxic T cell. After this cell will undergo lysis cell destruction. Following are the main points which display the difference between the humoral and the cell-mediated immunity:.
From the above content, we came to know about the few though critical differences between the two types of the active immune system which are a humoral and cell-mediated immune response. We concluded that both the types of immunity differ in the process of destroying the pathogens, where antigens specific antibodies are produced rapidly against the antigens, while in cell-mediated immunity the pathogens are destroyed through cell lysis.
Your email address will not be published. Save my name, email, and website in this browser for the next time I comment. Key Differences Between Humoral and Cell-Mediated Immunity Following are the main points which display the difference between the humoral and the cell-mediated immunity: The humoral immunity is associated with the B-lymphocytes and is responsible for destroying the pathogens by producing antibodies against it, whereas the cell-mediated immunity is associated with the T-lymphocytes and is responsible for the destroying the pathogens or microorganism which have invaded the cells without producing antibodies.
Humoral immunity is intimately associated with B-lymphocytes, T-lymphocytes, and macrophages, on the contrary, the cell-mediated immunity is associated with T-lymphocytes, helper T cells, natural killer cells, and macrophages.
Humoral immunity plays a major role in recognizing antigen or any foreign particle and in producing antibodies against it. It is known for working against extracellular pathogens. Cell-mediated immunity is related to T-lymphocytes, which work by identifying viruses and microorganisms, thus destroying them by the cell lysis or phagocytosis or pinocytosis.
Humoral immunity secretes antibodies to fight against antigens, whereas cell-mediated immunity secretes cytokines and no antibodies to attack the pathogens.
The Humoral immunity is rapid or quick in their action against antigens, while the Cell-mediated immunity show delay though permanent action against any pathogens. Humoral immunity is involved in an early stage of graft rejections due to the formation of antibodies against any foreign particle, while Cell-mediated immunity is involved in the rejection of organ transplants after a certain time as they show delayed response.
Comments wow, thanks so much. Leave a Reply Cancel reply Your email address will not be published. The humoral immunity is associated with the B-lymphocytes and is responsible for destroying the pathogens by producing antibodies against it. Humoral immunity is intimately associated with B-lymphocytes, T-lymphocytes and macrophages. Humoral immunity is involved in the early stage of graft rejections due to the formation of antibodies.
11.5A: Humoral Immune Response
Abstract Ann M. Tisch, Arlene E. Dent, Chandy C. John, Carole A. Long, John Vulule, James W.
The lymphatic system houses large populations of immune cells which are released upon detection of a pathogen. Lymph, the watery fluid that bathes tissues and organs, contains protective white blood cells, but does not contain erythrocytes red blood cells. Lymph moves about the body through the lymphatic system, which is made up of vessels, lymph ducts, lymph glands, and organs such as tonsils, adenoids, thymus, and spleen. Although the immune system is characterized by circulating cells throughout the body, the regulation, maturation, and intercommunication of immune factors occur at specific sites that are known as lymph nodes. The blood circulates immune cells, proteins, and other factors through the body.
Discoveries made over the past ten years have provided evidence that invertebrate antiparasitic responses may be primed in a sustainable manner, leading to the failure of a secondary encounter with the same pathogen. The demonstration of this process remains to be obtained and the underlying mechanisms remain to be discovered and exhaustively tested with rigorous functional and molecular methods, to eliminate all alternative explanations. In order to achieve this ambitious aim, the present study focuses on the Lophotrochozoan snail, Biomphalaria glabrata , in which innate immune memory was recently reported.